Policy change has been the leading driver of some of the nation’s greatest public health successes. The most effective public health policy changes are guided by certain principles: they are evidence-based, they consider equity, they are designed with implementation in mind and they effectively translate research into policy solutions. They are also designed with input from all stakeholders – including those outside of the traditional world of public health. Policies in a wide variety of sectors, including education, transportation, criminal justice and others, have profound impacts on health and well-being. In order to most effectively and comprehensively address our five key challenges, we must promote a collaborative approach to policy changes and implementation.