In the era of open data and transparency, advances have been made in the use of evidence to drive public health policy and practice. But the divide between research and practice still looms large. Too often, the kind of evidence produced through rigorous academic research does not line up with the data needs of policymakers and practitioners. And policymakers and practitioners too often rely on evidence from weak study designs, if they use evidence at all. As we work to address some of the most pressing challenges to American public health, we must bring together researchers, practitioners, and policymakers to ensure that the research conducted and used to guide practice balances rigor and relevance. We must also look to innovative study designs and creative ways to make data and results more accessible.